In Tibetan Buddhism, Vajravārāhī is a wrathful form of Vajrayogini associated particularly with the Cakrasaṃvara Tantra, where she is paired in yab-yum with the Heruka Cakrasaṃvara. Judith Simmer-Brown writes that "Vajravārāhī's iconography is very similar to that of Vajrayoginī, but she often has more prominent fangs and a more wrathful expression, and she prominently displays a sow's head above her right ear."

Vajrayoginī is an important figure in Buddhism, especially revered in Tibetan Buddhism. In Vajrayana she is considered a female Buddha and a ḍākiṇī. Vajrayoginī is often described with the epithet sarvabuddhaḍākiṇī, meaning "the ḍākiṇī [who is the Essence] of all Buddhas". She is an Anuttarayoga Tantra meditational deity (iṣṭadevatā) and her practice includes methods for preventing ordinary death, intermediate state (bardo) and rebirth (samsara) by transforming them into paths to enlightenment, and for transforming all mundane daily experiences into higher spiritual paths.