Van Buren was the codename of a canceled role-playing video game developed by Black Isle Studios. It was intended to be the third game in the mainline Fallout series. Set in the year 2253, the plot of Van Buren revolved around a prisoner who would explore the American Southwest while being chased by robotic prison guards. The main antagonist was a mad scientist named Victor Presper, who planned on using the prisoner as an inadvertent vector to spread a deadly virus. Gameplay would have included a mixture of real-time and turn-based combat. The player would explore the map with a team of non-playable character (NPC) companions. Each NPC would make their own independent decisions which would affect the story.

Chris Avellone is an American video game designer and comic book writer. He worked for Interplay and Obsidian Entertainment before becoming a freelance designer and writer. He is best known for his work on role-playing video games such as Planescape: Torment, Star Wars Knights of the Old Republic II: The Sith Lords and the Fallout series.