Vannevar Bush was an American engineer, inventor and science administrator, who during World War II headed the U.S. Office of Scientific Research and Development (OSRD), through which almost all wartime military R&D was carried out, including important developments in radar and the initiation and early administration of the Manhattan Project. He emphasized the importance of scientific research to national security and economic well-being, and was chiefly responsible for the movement that led to the creation of the National Science Foundation.

The Manhattan Project was a program of research and development undertaken during World War II to produce the first nuclear weapons. It was led by the United States in collaboration with the United Kingdom and Canada. From 1942 to 1946, the project was under the direction of Major General Leslie Groves of the U.S. Army Corps of Engineers. Nuclear physicist J. Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the bombs. The Army program was designated the Manhattan District, as its first headquarters were in Manhattan; the name gradually superseded the official codename, Development of Substitute Materials, for the entire project. The project absorbed its earlier British counterpart, Tube Alloys. The Manhattan Project employed nearly 130,000 people at its peak and cost nearly US$2 billion, over 80 percent of which was for building and operating the plants that produced the fissile material. Research and production took place at more than 30 sites across the US, the UK, and Canada.