Varkey Vithayathil CSsR was an Indian cardinal who served as the Major Archbishop of the Syro-Malabar Catholic Church and Archeparchy of Ernakulam-Angamaly from 1999 to 2011. He was also a religious priest of the Congregation of the Most Holy Redeemer.

The Syro-Malabar Church, also known as the Syro-Malabar Catholic Church, is an Eastern Catholic Church based in Kerala, India. It is a sui iuris (autonomous) particular church in full communion with the Holy See and the worldwide Catholic Church, with self-governance under the Code of Canons of the Eastern Churches (CCEO). The major archbishop presides over the entire church. The incumbent Major Archbishop is Raphael Thattil, serving since January 2024. The Syro-Malabar Synod of Bishops canonically convoked and presided over by the major archbishop constitutes the supreme authority of the church. The Major Archiepiscopal Curia of the church is based in Kakkanad, Kochi. Syro-Malabar is a prefix reflecting the church's use of the East Syriac Rite liturgy and origins in Malabar. The name has been in usage in official Vatican documents since the nineteenth century.