Vazgen Mikayeli Manukyan is an Armenian politician who served as the first Prime Minister of Armenia from 1990 to 1991. From 1992 to 1993, during the First Nagorno-Karabakh War, Manukyan was acting Defence Minister of Armenia. He was also a member of Armenia's parliament from 1990 to 2007.

The prime minister of Armenia is the head of government and most senior minister within the Armenian government, and is required by the constitution to "determine the main directions of policy of the Government, manage the activities of the Government and coordinate the work of the members of the Government." Also, according to the constitution, the prime minister heads the Security Council, which prescribes the main directions of the country's defense policy; thus, the prime minister is effectively the commander-in-chief of the Armed Forces of Armenia. Nikol Pashinyan is the current prime minister. He took the office on 8 May 2018 following the resignation of Serzh Sargsyan.