Vendôme is a subprefecture of the department of Loir-et-Cher, France. It is also the department's third-biggest commune with 15,856 inhabitants (2019).

Loir-et-Cher is a department in the Centre-Val de Loire region of France. Its name is originated from two rivers which cross it, the Loir in its northern part and the Cher in its southern part. Its prefecture is Blois. The INSEE and La Poste gave it the number 41. It had a population of 329,470 in 2019.