The Venetian Ghetto was the area of Venice in which Jews were forced to live by the government of the Venetian Republic. The English word ghetto is derived from the Jewish ghetto in Venice. The Venetian Ghetto was instituted on 29 March 1516 by decree of Doge Leonardo Loredan and the Venetian Senate. It was not the first time that Jews in Venice were compelled to live in a segregated area of the city. In 1555, Venice had 160,208 inhabitants, including 923 Jews, who were mainly merchants.

Venice is a city in northeastern Italy and the capital of the Veneto region. It is built on a group of 126 islands that are separated by expanses of open water and by canals; portions of the city are linked by 472 bridges. The islands are in the shallow Venetian Lagoon, an enclosed bay lying between the mouths of the Po and the Piave rivers. In 2020, around 258,685 people resided in greater Venice or the Comune di Venezia, of whom around 51,000 live in the historical island city of Venice and the rest on the mainland (terraferma). Together with the cities of Padua and Treviso, Venice is included in the Padua-Treviso-Venice Metropolitan Area (PATREVE), which is considered a statistical metropolitan area, with a total population of 2.6 million.