Vercelli Cathedral is the principal church of the city of Vercelli in Piedmont, Italy, and the cathedral of the Archdiocese of Vercelli. It is dedicated to Saint Eusebius of Vercelli, the first bishop.

Vercelli is a city and comune of 46,552 inhabitants in the Province of Vercelli, Piedmont, northern Italy. One of the oldest urban sites in northern Italy, it was founded, according to most historians, around 600 BC.