The vesicular monoamine transporter is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, sero
A Hydrogen atom from the inside of the vesicle binds, inducing a conformational change in the transporter
The conformational change induced by the hydrogen atom binding enables the monoamine binding to the active transport site
A second hydrogen atom binds from inside the vesicle to the transporter inducing another change
The monoamine is released inside the vesicle and the two hydrogen atoms are released into the cytosol and the transport process starts over again.
Synaptic vesicle
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In a neuron, synaptic vesicles store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating
Vesicular monoamine transporter
…The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the…
Primary hippocampal neurons observed at 10 days in vitro by confocal microscopy. In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm.
A dynamin 1 dynamin 3 and clathrin independent pathway of synaptic vesicle recycling mediated by elife 01621fs 001