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A Hydrogen atom from the inside of the vesicle binds, inducing a conformational change in the transporter
A Hydrogen atom from the inside of the vesicle binds, inducing a conformational change in the transporter
The conformational change induced by the hydrogen atom binding enables the monoamine binding to the active transport site
The conformational change induced by the hydrogen atom binding enables the monoamine binding to the active transport site
A second hydrogen atom binds from inside the vesicle to the transporter inducing another change
A second hydrogen atom binds from inside the vesicle to the transporter inducing another change
The monoamine is released inside the vesicle and the two hydrogen atoms are released into the cytosol and the transport process starts over again.
The monoamine is released inside the vesicle and the two hydrogen atoms are released into the cytosol and the transport process starts over again.
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Synaptic vesicle
Synaptic vesicle
Primary hippocampal neurons observed at 10 days in vitro by confocal microscopy. In both images neurons are stained with a somatodendritic marker, mic
Primary hippocampal neurons observed at 10 days in vitro by confocal microscopy. In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm.