Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. These complexes concentrate the
An overview of the trafficking of some adaptor protein (AP) complexes.
Adaptor Protein complexes and COPI-F subcomplex.
More trafficking pathways. Note, the colors are not the same as in the lead figure
The evolution of TSET, COPI and APs from the Last Eukaryotic Common Ancestor
AP2 adaptor complex
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The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give rise to a stru
Vesicular transport adaptor protein
…there are two large proteins (~100 kD) and two smaller proteins. One of the large proteins is termed β (beta), with β1 in the AP-1 complex, β2 in the AP-2 complex, and so on. The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha), AP-3 has…
AP2 Adaptor Complex Cryo-EM Structure. Red - alpha subunits. Blue - beta subunit. Green - mu subunit. Yellow - sigma subunit.