Vesta is the virgin goddess of the hearth, home, and family in Roman religion. She was rarely depicted in human form, and was more often represented by the fire of her temple in the Forum Romanum. Entry to her temple was permitted only to her priestesses, the Vestal Virgins. Their virginity was deemed essential to Rome's survival; if found guilty of inchastity, they were buried or entombed alive. As Vesta was considered a guardian of the Roman people, her festival, the Vestalia, was regarded as one of the most important Roman holidays. During the Vestalia privileged matrons walked barefoot through the city to the temple, where they presented food-offerings. Such was Vesta's importance to Roman religion that following the rise of Christianity, hers was one of the last non-Christian cults still active, until it was forcibly disbanded by the Christian emperor Theodosius I in AD 391.

In Greek and Roman mythology, several goddesses are distinguished by their perpetual virginity. These goddesses included the Greek deities Hestia, Athena, and Artemis, along with their Roman equivalents, Vesta, Minerva, and Diana. In some instances, the inviolability of these goddesses was simply a detail of their mythology, while in other cases virginity was also associated with their worship and religious rites.