Vestal High School is a public high school that operates as part of the Vestal Central School District which encompasses 57 square miles (150 km2) just west of Binghamton in the Southern Tier of New York. It is a four-year comprehensive school which annually receives both national and state recognition for excellence in education. The high school offers Varsity and Junior Varsity sports as well as musical opportunities in orchestra, band, and chorus. Clubs and student organizations accommodate a wide range of interests, from the physical sciences to martial arts. The mascot of Vestal High School is the Golden Bear named Bruin. Vestal High School holds an annual dance named after the mascot called the King Bruin dance, or KB. Unlike most high schools, Vestal High School does not have a Homecoming dance, but instead a football game and later in the year the King Bruin dance.

Vestal is a town within Broome County in the Southern Tier of New York, United States, and lies between the Susquehanna River and the Pennsylvania border. As of the 2020 census, the population was 29,110. Vestal is on the southern border of the county, and serves as a western suburb of the city of Binghamton. The town is home to the main campus of Binghamton University.