The Vice Premier of the Republic of China serves as the deputy to the premier and is appointed by the president, on the recommendation of the Premier. The title of vice premier had been changed several times, so this list is divided into several sections. This includes both vice premiers of the Republic of China before 1949, when the seat of government was in Mainland China, and vice premiers since 1949, when the seat of government was relocated to Taiwan.

Chang Li-sheng was a Chinese politician and diplomat who served as the Secretary General of the Kuomintang from 1954 to 1959. L.S. Chang as he was commonly known, played a key role in Republic of China (ROC)'s political, economic, financial, and foreign affairs as well as in Kuomintang affairs from the 1920s until his death in Taiwan in 1971. Throughout his political life over four decades, Chang served in numerous important posts within both the KMT and the ROC's local and central governments. He was a rare example of Chinese political virtues, noted for his integrity and honesty. He is remembered for numerous achievements and deeds, including his role in assisting Chen Cheng (1897–1965), former Taiwan provincial governor, Premier, and Vice President, to launch Taiwan's local autonomy, economic and land reforms.