The vice president of the Islamic Republic of Afghanistan was the second highest political position attainable in the Islamic Republic of Afghanistan. The vice presidents were elected on the same ticket as the president. A presidential candidate was responsible for nominating two candidates for vice president before the election.

The Islamic Republic of Afghanistan was a presidential republic that ruled Afghanistan from 2004 to 2021. The state was established to replace the Afghan interim (2001–2002) and transitional (2002–2004) administrations, which were formed after the 2001 United States invasion of Afghanistan that had toppled the partially recognized Taliban-ruled Islamic Emirate of Afghanistan. However, on 15 August 2021, the country was recaptured by the Taliban, which marked the end of the 2001–2021 war, the longest war in US history. This led to the overthrow of the Islamic Republic, led by President Ashraf Ghani, and the reinstatement of the Islamic Emirate under the control of the Taliban. While the United Nations still recognizes the Islamic Republic as the legitimate government of Afghanistan, this toppled regime controls no portion of the country today, nor does it operate in exile; it effectively no longer exists. The Islamic Emirate is the de facto ruling government. The US–Taliban deal, signed on 29 February 2020 in Qatar, was one of the critical events that caused the collapse of the Afghan National Security Forces (ANSF). Following the deal, the US dramatically reduced the number of air attacks and deprived the ANSF of a critical edge in fighting the Taliban insurgency, leading to the Taliban takeover of Kabul.