The vice president of Syria is a political position in Syria. The Constitution states that in the case of the president's temporary disablement, the vice president may become acting president. Multiple people can hold the office of vice presidency at the same time. The president of Syria appoints vice presidents.

Akram Al-Hourani, was a Syrian politician who played a prominent role during the democratic era of Syria in the 1950s, he established and led the Arab Socialist Party. He was a highly influential figure in the Syrian politics from the beginning of the 1940s until his departure into exile in 1963, during this period he was able to introduce significant reforms towards more just and fairer society especially in relation to the agricultural sector and land redistribution against the feudal system. Al-Hourani held various positions as a member of the Syrian parliament, the head of the parliament, minister of agriculture, minister of defence, and the vice-president of the United Arab Republic. He is the grandfather of Akram Al-Hourani, a lecturer and researcher in wireless network engineering and signal processing at RMIT University in Australia.