The vice president of the Dominican Republic is the second-highest political position in the Dominican Republic. The vice president is the first person in the presidential line of succession, ascending to the presidency upon the death, resignation, or removal of the president. There have been thirty-nine vice presidents of the Dominican Republic. Under the Constitution of the Dominican Republic, the vice president shall be elected along with the president.

Manuel de Regla Mota y Álvarez was a Dominican military figure and politician. Mota served as the 5th president of the Dominican Republic from May 26, 1856, until October 8, 1856. Prior to that he served as the country's vice president under Pedro Santana.