The vice president of the Dominican Republic is the second-highest political position in the Dominican Republic. The vice president is the first person in the presidential line of succession, ascending to the presidency upon the death, resignation, or removal of the president. There have been thirty-nine vice presidents of the Dominican Republic. Under the Constitution of the Dominican Republic, the vice president shall be elected along with the president.

Gregorio Luperón was a Dominican revolutionary, military general, businessman, liberal politician, freemason, and Statesman who was one of the leaders in the Dominican Restoration War. Luperón was an active member of the Triunvirato of 1866, becoming the President of the Provincial Government in San Felipe de Puerto Plata, and after the successful coup against Cesareo Guillermo, he became the 28th President of the Dominican Republic.