Villa Boscoreale is a name given to any of several Roman villas discovered in the district of Boscoreale, Italy. They were all buried and preserved by the eruption of Mount Vesuvius in 79 AD, along with Pompeii and Herculaneum. The only one visible in situ today is the Villa Regina, the others being reburied soon after their discovery. Although these villas can be classified as "rustic" rather than of otium due to their agricultural sections and sometimes lack of the most luxurious amenities, they were often embellished with extremely luxurious decorations such as frescoes, testifying to the wealth of the owners. Among the most important finds are the exquisite frescoes from the Villa of Publius Fannius Synistor and the sumptuous Boscoreale Treasure of the Villa della Pisanella, which is now displayed in several major museums.

Of the many eruptions of Mount Vesuvius, a major stratovolcano in Southern Italy, the best-known is its eruption in 79 AD, which was one of the deadliest in history.