Villanova station is a SEPTA Regional Rail station on the campus of Villanova University in Villanova, Pennsylvania. It is in Radnor Township, located on North Spring Mill Road near County Line Road and serves most Paoli/Thorndale Line trains.

The SEPTA Regional Rail system is a commuter rail network owned by SEPTA and serving the Philadelphia metropolitan area. The system has 13 branches and more than 150 active stations in Philadelphia, Pennsylvania, its suburbs and satellite towns and cities. It is the sixth-busiest commuter railroad in the United States, and the busiest outside of the New York, Chicago, and Boston metropolitan areas. In 2016, the Regional Rail system had an average of 132,000 daily riders and 118,800 daily riders as of 2019.