Vin Mariani was a coca wine and patent medicine created in the 1860s by Angelo Mariani, a French chemist from the island of Corsica. Mariani became intrigued with coca and its medical and economic potential after reading Paolo Mantegazza's paper on the effects of coca. Between 1863 and 1868 Mariani started marketing a coca wine called Vin Tonique Mariani which was made from Bordeaux wine and coca leaves.

Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine.