State Route 106 is a primary state highway in the U.S. state of Virginia. The state highway runs 30.00 miles (48.28 km) from U.S. Route 460 and US 460 Business in Petersburg north to SR 249 in Talleysville. SR 106 connects Prince George County in the southern part of the Richmond–Petersburg metropolitan area with Charles City and New Kent counties on the Virginia Peninsula via the Benjamin Harrison Memorial Bridge over the James River.

U.S. Route 460 (US 460) in Virginia runs west-east through the southern part of the Commonwealth. The road has two separate pieces in Virginia, joined by a relatively short section in West Virginia. Most of US 460 is a four-lane divided highway and is a major artery in the southern third of the state. From Petersburg to Suffolk, US 460 is a four-lane non-divided highway. It is a popular alternative to Interstate 64 (I-64) when going from Richmond and other points in central Virginia to the Currituck Sound and Outer Banks of North Carolina, avoiding the congestion and tunnels of the more northerly I-64 corridor. The road passes through several small towns that built up at stops along the railroad line.