State Route 160 is a primary state highway in the U.S. state of Virginia. Known as the Trail of the Lonesome Pine, the state highway runs 8.02 miles (12.91 km) from the Kentucky state line on top of Black Mountain, where the highway continues north as Kentucky Route 160, east to SR 68 in Appalachia. Due to the mountainous terrain and numerous tight bends, Virginia State Route 160 and its Kentucky State Route 160 counterpart are signposted closed to tractor-trailers between Lynch, KY and Appalachia, VA.

U.S. Route 23 (US 23) is a part of the United States Numbered Highway System that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In Virginia, the U.S. Highway runs 60.80 miles (97.85 km) from the Tennessee state line near Weber City north to the Kentucky state line near Pound. US 23, which is known as Orby Cantrell Highway for most of its course, is a four-lane divided highway that follows Corridor B of the Appalachian Development Highway System through Southwest Virginia. The U.S. Highway serves as the main east–west highway of Scott County and the primary north–south highway of Wise County. US 23 runs concurrently with US 58 from Weber City to Duffield and with US 58 Alternate between Big Stone Gap and the independent city of Norton.