State Route 161 is a primary state highway in and near Richmond, Virginia, United States. It extends from an interchange with Interstate 95 (I-95) in the independent city of Richmond north to an intersection with U.S. Route 1 in the Lakeside area of central Henrico County.

Interstate 95 (I-95) runs 179 miles (288 km) within the commonwealth of Virginia between its borders with North Carolina and Maryland. I-95 meets the northern terminus of I-85 in Petersburg and is concurrent with I-64 for three miles (4.8 km) in Richmond. Although I-95 was originally planned as a highway through Washington, D.C., it was rerouted along the eastern portion of the Capital Beltway concurrent with I-495. From Petersburg to Richmond, I-95 utilized most of the Richmond–Petersburg Turnpike, a former toll road. In addition to Richmond, the route also runs through the medium-sized cities of Emporia, Petersburg, Colonial Heights, Fredericksburg, and Alexandria.