State Route 2, formerly State Route 50, is a primary state highway in the U.S. state of Virginia. The state highway runs 53.08 miles (85.42 km) from U.S. Route 1 and US 301 in Richmond north to US 1 Business, US 17 Business, and SR 3 Business in Fredericksburg. SR 2 connects Richmond and Fredericksburg via Bowling Green. The state highway runs concurrently with US 301 from Richmond to Bowling Green and with US 17 Business in the Fredericksburg area.

U.S. Route 1 (US 1) is a major north–south U.S. Route that serves the East Coast of the United States. In the U.S. state of Virginia, US 1 runs north–south through South Hill, Petersburg, Richmond, Fredericksburg, and Alexandria on its way from North Carolina to the 14th Street bridges into the District of Columbia. It is completely paralleled by Interstate Highways in Virginia—Interstate 85 (I-85) south of Petersburg, I-95 north to Alexandria, and I-395 into the District of Columbia—and now serves mainly local traffic. At its north end, on the approach to the 14th Street bridges, US 1 is concurrent with I-395; the rest of US 1 is on surface roads.