State Route 33 is a primary state highway in the U.S. state of Virginia. The state highway runs 72.23 miles (116.24 km) from U.S. Route 33 and US 250 in Richmond, Virginia east to Chesapeake Boulevard in Stingray Point. SR 33 is a state-numbered eastward extension of US 33 that connects Richmond with West Point and the Middle Peninsula, one of three large peninsulas on the west side of the Chesapeake Bay in Virginia. The state highway is a major thoroughfare in the downtown and East End areas of Richmond. SR 33 serves a suburban area in eastern Henrico County before running concurrently with US 60, Interstate 64 (I-64), and SR 30 east toward West Point. The state highway heads from West Point through Saluda, east of which SR 33 serves as the main highway of Middlesex County.

U.S. Route 33 is a part of the U.S. Highway System that runs from Elkhart, Indiana to Richmond, Virginia. In Virginia, the U.S. Highway runs 135.60 miles (218.23 km) from the West Virginia state line near Rawley Springs east to its eastern terminus at SR 33 in Richmond. US 33 is the primary east–west highway of Rockingham County, which lies in the Shenandoah Valley. The highway connects the independent city of Harrisonburg, the town of Elkton, and an entrance to Shenandoah National Park. East of the Blue Ridge Mountains, US 33 connects the Piedmont communities of Stanardsville, Gordonsville, and Louisa. The U.S. Highway is a major suburban and urban route in the Richmond metropolitan area. Within Richmond, US 33 runs concurrently with US 250. SR 33 continues from US 33's eastern terminus as a state-numbered extension of the U.S. Highway that connects Richmond with Virginia's Middle Peninsula.