State Route 39 is a primary state highway in the U.S. state of Virginia. The state highway runs 59.17 miles (95.22 km) from the West Virginia state line near Mountain Grove, where the highway continues as West Virginia Route 39, east to U.S. Route 11 in East Lexington. SR 39 connects Lexington with several communities formed around hot springs in Bath County. In Rockbridge County, the state highway passes through the town of Goshen and Goshen Pass, a gorge formed by the Maury River.

U.S. Route 11 (US 11) is a north–south United States Numbered Highway in western Virginia. At 339 miles (546 km), it is the second longest numbered route and longest primarily north–south route in the state. It enters the state from Tennessee as the divided routes US 11E and US 11W at Bristol, roughly follows the West Virginia border through the Blue Ridge Mountains and Shenandoah Valley, and enters the Eastern Panhandle of West Virginia from Frederick County. Most of the route closely parallels I-81. From south to north, US 11 serves the cities and towns of Bristol, Abingdon, Wytheville, Pulaski, Radford, Christiansburg, Roanoke, Lexington, Staunton, Harrisonburg, Strasburg, and Winchester. As one of the original U.S. Highways, it was first designated through Virginia in 1926 and has largely followed the same route since. Prior to the construction of the Interstate Highway System, it was the primary long-distance route for traversing the western part of the state. Much of it roughly follows the Great Wagon Road, a colonial-era road that followed the Appalachian Mountains from Georgia to Pennsylvania.