Vitalism is a belief that starts from the premise that "living organisms are fundamentally different from non-living entities because they contain some non-physical element or are governed by different principles than are inanimate things." Where vitalism explicitly invokes a vital principle, that element is often referred to as the "vital spark", "energy", "élan vital", "vital force", or "vis vitalis", which some equate with the soul. In the 18th and 19th centuries, vitalism was discussed among biologists, between those who felt that the known mechanics of physics would eventually explain the difference between life and non-life and vitalists who argued that the processes of life could not be reduced to a mechanistic process. Vitalist biologists such as Johannes Reinke proposed testable hypotheses meant to show inadequacies with mechanistic explanations, but their experiments failed to provide support for vitalism. Biologists now consider vitalism in this sense to have been refuted by empirical evidence, and hence regard it either as a superseded scientific theory, or, since the mid-20th century, as a pseudoscience.

This list catalogs well-accepted theories in science and pre-scientific natural philosophy and natural history which have since been superseded by scientific theories. Many discarded explanations were once supported by a scientific consensus, but replaced after more empirical information became available that identified flaws and prompted new theories which better explain the available data. Pre-modern explanations originated before the scientific method, with varying degrees of empirical support.