In the Middle Ages, the Volga trade route connected Northern Europe and Northwestern Russia with the Caspian Sea and the Sasanian Empire, via the Volga River. The Rus used this route to trade with Muslim countries on the southern shores of the Caspian Sea, sometimes penetrating as far as Baghdad. The powerful Volga Bulgars formed a seminomadic confederation and traded through the Volga river with Viking people of Rus' and Scandinavia and with the southern Byzantine Empire Furthermore, Volga Bulgaria, with its two cities Bulgar and Suvar east of what is today Moscow, traded with Russians and the fur-selling Ugrians. Chess was introduced to Medieval Rus via the Caspian-Volga trade routes from Persia and Arabia.

The Khazars were a nomadic Turkic people that, in the late 6th-century CE, established a major commercial empire covering the southeastern section of modern European Russia, southern Ukraine, Crimea, and Kazakhstan. They created what for its duration was the most powerful polity to emerge from the break-up of the Western Turkic Khaganate. Astride a major artery of commerce between Eastern Europe and Southwestern Asia, Khazaria became one of the foremost trading empires of the early medieval world, commanding the western marches of the Silk Road and playing a key commercial role as a crossroad between China, the Middle East and Kievan Rus'. For some three centuries the Khazars dominated the vast area extending from the Volga-Don steppes to the eastern Crimea and the northern Caucasus.