Vologases IV was King of Kings of the Parthian Empire from 147 to 191. He was the son of Mithridates V. Vologases spent the early years of his reign re-asserting Parthian control over the Kingdom of Characene. From 161 to 166, he waged war against the Roman Empire; although initially successful, conquering Armenia and Syria, he was eventually pushed back, briefly losing control of the Parthian capitals of Seleucia and Ctesiphon to the Romans. The Romans suffered heavy losses from a plague erupting from Seleucia in 166, forcing them to withdraw. The war ended soon afterward, with Vologases losing most of northern Mesopotamia to the Romans. He died in 191 and was succeeded by his son Vologases V.

Armenia, also the Kingdom of Greater Armenia, or simply Greater Armenia or Armenia Major sometimes referred to as the Armenian Empire, was a kingdom in the Ancient Near East which existed from 331 BC to 428 AD. Its history is divided into the successive reigns of three royal dynasties: Orontid, Artaxiad and Arsacid (52–428).