The W.E.B. Du Bois Boyhood Homesite is a National Historic Landmark in Great Barrington, Massachusetts, commemorating an important location in the life of African American intellectual and civil rights activist W.E.B. Du Bois (1868–1963). The site contains foundational remnants of the home of Du Bois' grandfather, where Du Bois lived for the first five years of his life. Du Bois was given the house in 1928, and planned to renovate it, but was unable to do so. He sold it in 1954 and the house was torn down later that decade.

Great Barrington is a town in Berkshire County, Massachusetts, United States. It is part of the Pittsfield, Massachusetts, Metropolitan Statistical Area. The population was 7,172 at the 2020 census. Both a summer resort and home to Ski Butternut, a ski resort, Great Barrington includes the villages of Van Deusenville and Housatonic.