WEC 46: Varner vs. Henderson was a mixed martial arts event held by World Extreme Cagefighting on January 10, 2010. It took place at the ARCO Arena in Sacramento, California.

Eddie Wineland is an American retired mixed martial artist, who competed in the Bantamweight division of the Ultimate Fighting Championship (UFC). A professional competitor from 2003 until 2022, Wineland was the inaugural WEC Bantamweight Champion.