WEC 53: Henderson vs. Pettis was a mixed martial arts event held by World Extreme Cagefighting that took place on December 16, 2010 at Jobing.com Arena in the Phoenix suburb of Glendale, Arizona. The event was the first time that Zuffa has hosted an event in Arizona. This was the final WEC event, due to the merger with the UFC.

Brad Pickett is an English former mixed martial artist. He is a former Cage Rage British Featherweight Champion. He competed as a bantamweight in the Ultimate Fighting Championship; Dana White stated that Pickett was one of his favourite fighters to watch. He has also competed for World Extreme Cagefighting and BodogFIGHT, and at the Dynamite!! USA event.