WMNE was a pioneer commercial FM radio station, which was the second of two mountain-top broadcasting stations established by the Yankee Network. It began regular programming, as experimental station W1XER, in December 1940. In 1941 it was licensed for commercial operation from studios in Boston, initially with the call sign W39B, which was changed to WMTW in 1943. In late 1946 the station's designated community of license was changed to Portland, Maine, and its call letters became WMNE.

The Yankee Network was an American radio network, based in Boston, Massachusetts, with affiliate radio stations throughout New England. At the height of its influence, the Yankee Network had as many as twenty-four affiliated radio stations. The network was co-founded by John Shepard III and his brother Robert, in 1929–1930. The beginnings of what became the Yankee Network occurred in the mid-1920s, when John Shepard's Boston station WNAC linked by telephone land lines with Robert Shepard's station in Providence, Rhode Island, WEAN, so that the two stations could share or exchange programming. Those two stations became the first two Yankee Network stations. In 1930, they were joined by the first affiliated radio stations, including WLBZ in Bangor, Maine; WORC in Worcester, Massachusetts; WNBH in New Bedford, Massachusetts; and WICC in Bridgeport, Connecticut. During the 1930s, the network became known for developing its own local and regional news bureau, the Yankee News Service. The Yankee Network and the Yankee News Service operated until February 1967.