WYFF is a television station in Greenville, South Carolina, United States, serving Upstate South Carolina and Western North Carolina as an affiliate of NBC. Owned by Hearst Television, the station maintains studios on Rutherford Street in northwest Greenville, and its transmitter is located near Caesars Head State Park in northwestern Greenville County.

The Upstate, historically known as the Upcountry, is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.