Wabasso is an unincorporated community and census-designated place (CDP) in Indian River County, Florida, United States. The population was 609 at the 2010 census, down from 918 at the 2000 census. It is located at the intersection of U.S. 1 and SR 510.

U.S. Highway 1 (US 1) in Florida runs 545 miles (877 km) along the state's east coast from Key West to its crossing of the St. Marys River into Georgia north of Boulogne and south of Folkston. US 1 was designated through Florida when the U.S. Numbered Highway System was established in 1926. With the exception of Monroe County, the highway runs through the easternmost tier of counties in the state, connecting numerous towns and cities along its route, including nine county seats. The road is maintained by the Florida Department of Transportation (FDOT).