Wadjet, known to the Greek world as Uto or Buto among other renderings including Wedjat, Uadjet, and Udjo, was originally the ancient Egyptian local goddess of the city of Dep or Buto in Lower Egypt, which was an important site in prehistoric Egypt. Wadjet's worship originally started in the Predynastic period, but evolved over time from a local goddess to a patron goddess.

In Ancient Egyptian texts, the "Two Ladies" was a religious epithet for the goddesses Wadjet and Nekhbet, two deities who were patrons of the ancient Egyptians and worshiped by all after the unification of its two parts, Lower Egypt, and Upper Egypt. When the two parts of Egypt were joined together, there was no merger of these deities as often occurred with similar deities from various regions and cities. Both goddesses were retained because of the importance of their roles and they became known as the Two Ladies, who were the protectors of unified Egypt.