The Wagon Wheel Motel, Café and Station in Cuba, Missouri, is a 19-room independently owned historic U.S. Route 66 restored motel which has been serving travelers since 1938. The site opened as a café in 1936; the motel has remained in continuous operation since 1938. The motel rooms were fully restored in 2010, adding modern amenities such as HDTV and wireless Internet.

Cuba is a city in Crawford County, Missouri, United States. The population was 3,356 at the 2010 census. Cuba is the largest city situated entirely in Crawford County.