Waikerie is a rural town in the Riverland region of South Australia on the south bank of the Murray River. At the 2016 census, Waikerie had a population of 2,684. The Sturt Highway passes to the south of the town at the top of the cliffs. There is a cable ferry crossing the river to provide vehicle access from the north side of the river. Waikerie is known for citrus growing, along with stone fruit and grapes.

The Riverland is a region of South Australia. It covers an area of 9,386 square kilometres (3,624 sq mi) along the River Murray from where it flows into South Australia from New South Wales and Victoria downstream to Blanchetown. The major town centres are Renmark, Berri, Loxton, Waikerie, Barmera and Monash, and many minor townships. The population is approximately 35,000 people.