Wales is a town in Erie County, New York, United States. The town is one of the "Southtowns" of Erie County by virtue of its position in the southeast part of the county, southeast of Buffalo. As of the 2010 census the town had a population of 3,005.

New York State Route 400 (NY 400) is a 16.91-mile (27.21 km) freeway located within Erie County, New York, in the United States. The northwest end is connected to the New York State Thruway and the southeast end terminates at NY 16 in the town of Aurora. NY 400, known as the Aurora Expressway, roughly parallels NY 16 between the two locations. It is most commonly used to carry traffic from Buffalo to the village of East Aurora, where Fisher-Price and Moog, Inc are headquartered. It is a busy commuter route to the southern suburbs. NY 400 is signed as a north–south route, although about half of the route runs more east–west.