State Route 397 (SR 397) is a state highway in the U.S. state of Washington, serving the Tri-Cities region. It primarily functions as a truck route through industrial areas in Finley, Kennewick, and Pasco, running 22 miles (35 km) between junctions with Interstate 82 (I-82) and I-182. The highway crosses the Columbia River on the Cable Bridge, built in 1978 to replace an earlier bridge.

The Tri-Cities are three closely linked cities at the confluence of the Yakima, Snake, and Columbia Rivers in the Columbia Basin of Eastern Washington. The cities border one another, making the Tri-Cities seem like one uninterrupted mid-sized city. The three cities function as the center of the Tri-Cities metropolitan area, which consists of Benton and Franklin counties. The Tri-Cities urban area consists of the city of West Richland, the census-designated places (CDP) of West Pasco, Washington and Finley, as well as the CDP of Burbank, despite the latter being located in Walla Walla County.