State Route 500 (SR 500) is a state highway in Clark County, Washington, United States. The east–west highway runs through Vancouver as an expressway and its eastern suburbs as a country road, connecting Interstate 5 (I-5) to I-205 in eastern Vancouver and SR 14 in Camas. SR 500 runs concurrent to SR 503 within Orchards and also uses a section of the county-built Padden Parkway.

Clark County is the southernmost county in the U.S. state of Washington. As of the 2020 census, the population was 503,311, making it Washington's fifth-most populous county. Its county seat and largest city is Vancouver. It was the first county in Washington, first named Vancouver County in 1845 before being renamed for William Clark of the Lewis and Clark Expedition in 1849. It was created by the Provisional Government of Oregon in Oregon Country on August 20, 1845, and at that time covered the entire present-day state. Clark County is the third-most-populous county in the Portland-Vancouver-Hillsboro Metropolitan Statistical Area, and is across the Columbia River from Portland, Oregon.