Wayne is a county in the Commonwealth of Pennsylvania. The county's population was 51,155 at the 2020 census. The county seat is the Borough of Honesdale. The county was formed from part of Northampton County on March 21, 1798, and was named for the Revolutionary War General Anthony Wayne. The county is part of the Northeast Pennsylvania region of the state.

The Lackawanna River is a 42-mile-long (68 km) tributary of the Susquehanna River in Northeastern Pennsylvania. It flows through a region of the northern Pocono Mountains that was once a center of anthracite coal mining in the United States. It starts in north Wayne County, Pennsylvania and ends in east Luzerne County, Pennsylvania in Duryea, Pennsylvania. The lower reaches of the river flow through the urban areas of Scranton, which grew around its banks in the 19th century as an industrial center. Its name comes from a Lenape word meaning "stream that forks".