Wayne County is a county located in south central Tennessee, along the Alabama border. As of the 2020 census, the population was 16,232. Its county seat is Waynesboro. The county is named after General "Mad Anthony" Wayne, a prominent military leader in the American Revolutionary War.

Waynesboro is a city in and the county seat of Wayne County, Tennessee, United States. The population was 2,449 at the 2010 census, up from 2,228 in 2000.