Wayne County is the westernmost county in the U.S. state of West Virginia. As of the 2020 census, the population was 38,982. Its county seat is Wayne. The county was founded in 1842 and named for General "Mad" Anthony Wayne. Wayne County is part of the Huntington–Ashland, WV–KY–OH Metropolitan Statistical Area.

Wayne is a town in and the county seat of Wayne County, West Virginia, United States. The population was 1,441 at the 2020 census. It is part of the Huntington–Ashland metropolitan area.