Wayne Leon Graham is an American former head coach of the Rice Owls baseball team in Houston, Texas. He has coached one College World Series championship team and five NJCAA World Series championship teams. Also a former professional baseball player, Graham played in Major League Baseball (MLB) for the Philadelphia Phillies and New York Mets.

The Rice Owls baseball team is the interscholastic baseball team representing Rice University in Houston, Texas, United States. The Owls have appeared often in the NCAA tournament since the tenure of head coach Wayne Graham began in 1992. The program participated in every tournament from 1995 until 2017, and won the national championship in 2003, the first national championship for Rice athletics in any team sport.