The Wayne National Forest is located in the south-eastern part of the US state of Ohio, in the Unglaciated Allegheny Plateau. It is the only national forest in Ohio. Forest headquarters are located between The Plains and Nelsonville, Ohio, on US Route 33 overlooking the Hocking River.

Nelsonville is a city in northwestern Athens County, Ohio, United States, located about 60 miles (97 km) southeast of Columbus. The population was 5,373 at the 2020 census. It is home to Hocking College as well as Rocky Brands. Nelsonville is surrounded by Ohio's only national forest, the Wayne National Forest.