Wayne State College (WSC) is a public college in Wayne, Nebraska. It is part of the Nebraska State College System and enrolls 4,202 students. The college opened as a public normal school in 1910 after the state purchased the private Nebraska Normal College. The State Normal College became State Normal School and Teacher's College in 1921. This was changed to Nebraska State Teachers College at Wayne in 1949 and the present name was adopted in 1963.

Wayne is a city in Wayne County, Nebraska, United States. The population was 5,660 at the 2010 census. It is the county seat of Wayne County and the home of Wayne State College.