Wayne station is a SEPTA Regional Rail station located in the western suburbs of Philadelphia in Wayne, Delaware County, Pennsylvania. It is served by most Paoli/Thorndale Line trains. It is in Radnor Township.

Wayne is an unincorporated community centered in Delaware County, Pennsylvania, United States, on the Main Line, a series of highly affluent Philadelphia suburbs located along the railroad tracks of the Pennsylvania Railroad and one of the wealthiest areas in the nation. While the center of Wayne is in Radnor Township, Wayne extends into both Tredyffrin Township in Chester County and Upper Merion Township in Montgomery County. The center of Wayne was designated the Downtown Wayne Historic District in 2012. Considering the large area served by the Wayne post office, the community may extend slightly into Easttown Township, Chester County, as well.