The Waynesburg and Washington Railroad was a twenty-eight-mile, three-foot gauge subsidiary of the Pennsylvania Railroad. It started because of the boom in oil and gas, helped all of the natural resource industries to grow and spurred an increase in population in Waynesburg, Pennsylvania. Coal was already being mined on the eastern end of the county near the river.

Waynesburg is a borough in and the county seat of Greene County, Pennsylvania, United States, about 50 miles (80 km) south of Pittsburgh. Its population was 4,006 at the 2020 census.