Wellsville is a borough in York County, Pennsylvania, United States. The population was 299 at the 2020 census. It is part of the York–Hanover metropolitan area.

Pennsylvania Route 74 is a 96.4-mile-long (155.1 km) north–south state highway located in central Pennsylvania. The southern terminus of the route is at the Mason–Dixon line southwest of Delta, where the road continues into Maryland as Maryland Route 165. The northern terminus is at PA 75 south of Port Royal.