Wertheim was a large department store chain in pre-World War II Germany. It was founded by Georg Wertheim and operated various stores in Berlin, one in Rostock, one in Stralsund, and one in Breslau. Its Jewish owners were forced out after 1933 by the new Nazi government. After the war, owner Karstadt operated various store branches across Germany under the Wertheim name, all of which either closed or were rebranded Karstadt.

Georg Wertheim was a German merchant and founder of the popular Wertheim chain of department stores.